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anti il27 p28  (Bio X Cell)


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    Bio X Cell anti il27 p28
    (A) Schematic illustration of C134 and C027. C134 is a second-generation oHSV with deletion of the γ134.5 genes and insertion of the human cytomegalovirus (HCMV) IRS1 gene in the UL3/UL4 intergenic region. C027 was generated from C134 by insertion of bicistronic copies of murine IL-27 (mIL27) in the deleted γ134.5 regions under the MND promoter. (B) mIL27 <t>(p28)</t> secretion from C027 or C134 infected (MOI=1) CT-2A cell supernatants at 24- and 48-hours post-infection measured by ELISA. (C) Viral replication in CT-2A cells infected with C027, C134, or WT HSV (MOI=1) demonstrating viral replication kinetics. Experimental design schematics and representative Kaplan-Meier survival curves in (D) CT-2A (n=11 per cohort), (F) KR158 (n=5- 10 per cohort), and (H) SB28 (n=10 per cohort) immunocompetent syngeneic murine glioma models (Log- Rank test of significance) after treatment with Saline or equivalent PFU (1×10 7 ) of C027 or C134 (parental control). In vivo viral recovery from murine brain tumors (E) CT-2A, (G) KR158, and (I) SB28 at two days post- treatment with C134 (n=3) or C027 (n=3). For B, C, E, G, and I, data are mean ± SEM with each shape representing one replicate or animal. Statistical analyses were performed using two-way analysis of variance with Holm-Šídák’s correction for multiple comparisons (B), unpaired two-tailed Student’s t-test (E, G, and I), or Log-Rank tests of significance (D, F, and H). IC, intracranial; oHSV, oncolytic herpes simplex virus; PFU, plaque forming unit; MOI, multiplicity of infection; IL, interleukin; Tx, treatment.
    Anti Il27 P28, supplied by Bio X Cell, used in various techniques. Bioz Stars score: 94/100, based on 13 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/anti+il27+p28/InVivoMAb+anti-mouse+IL-27+p28/bio_rxiv__2025__05__12__653429-70-10-13
    Average 94 stars, based on 13 article reviews
    anti il27 p28 - by Bioz Stars, 2026-10
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    Images

    1) Product Images from "Oncolytic HSV-IL27 expression improves CD8 T cell function and therapeutic activity in syngeneic glioma models"

    Article Title: Oncolytic HSV-IL27 expression improves CD8 T cell function and therapeutic activity in syngeneic glioma models

    Journal: bioRxiv

    doi: 10.1101/2025.05.12.653429

    (A) Schematic illustration of C134 and C027. C134 is a second-generation oHSV with deletion of the γ134.5 genes and insertion of the human cytomegalovirus (HCMV) IRS1 gene in the UL3/UL4 intergenic region. C027 was generated from C134 by insertion of bicistronic copies of murine IL-27 (mIL27) in the deleted γ134.5 regions under the MND promoter. (B) mIL27 (p28) secretion from C027 or C134 infected (MOI=1) CT-2A cell supernatants at 24- and 48-hours post-infection measured by ELISA. (C) Viral replication in CT-2A cells infected with C027, C134, or WT HSV (MOI=1) demonstrating viral replication kinetics. Experimental design schematics and representative Kaplan-Meier survival curves in (D) CT-2A (n=11 per cohort), (F) KR158 (n=5- 10 per cohort), and (H) SB28 (n=10 per cohort) immunocompetent syngeneic murine glioma models (Log- Rank test of significance) after treatment with Saline or equivalent PFU (1×10 7 ) of C027 or C134 (parental control). In vivo viral recovery from murine brain tumors (E) CT-2A, (G) KR158, and (I) SB28 at two days post- treatment with C134 (n=3) or C027 (n=3). For B, C, E, G, and I, data are mean ± SEM with each shape representing one replicate or animal. Statistical analyses were performed using two-way analysis of variance with Holm-Šídák’s correction for multiple comparisons (B), unpaired two-tailed Student’s t-test (E, G, and I), or Log-Rank tests of significance (D, F, and H). IC, intracranial; oHSV, oncolytic herpes simplex virus; PFU, plaque forming unit; MOI, multiplicity of infection; IL, interleukin; Tx, treatment.
    Figure Legend Snippet: (A) Schematic illustration of C134 and C027. C134 is a second-generation oHSV with deletion of the γ134.5 genes and insertion of the human cytomegalovirus (HCMV) IRS1 gene in the UL3/UL4 intergenic region. C027 was generated from C134 by insertion of bicistronic copies of murine IL-27 (mIL27) in the deleted γ134.5 regions under the MND promoter. (B) mIL27 (p28) secretion from C027 or C134 infected (MOI=1) CT-2A cell supernatants at 24- and 48-hours post-infection measured by ELISA. (C) Viral replication in CT-2A cells infected with C027, C134, or WT HSV (MOI=1) demonstrating viral replication kinetics. Experimental design schematics and representative Kaplan-Meier survival curves in (D) CT-2A (n=11 per cohort), (F) KR158 (n=5- 10 per cohort), and (H) SB28 (n=10 per cohort) immunocompetent syngeneic murine glioma models (Log- Rank test of significance) after treatment with Saline or equivalent PFU (1×10 7 ) of C027 or C134 (parental control). In vivo viral recovery from murine brain tumors (E) CT-2A, (G) KR158, and (I) SB28 at two days post- treatment with C134 (n=3) or C027 (n=3). For B, C, E, G, and I, data are mean ± SEM with each shape representing one replicate or animal. Statistical analyses were performed using two-way analysis of variance with Holm-Šídák’s correction for multiple comparisons (B), unpaired two-tailed Student’s t-test (E, G, and I), or Log-Rank tests of significance (D, F, and H). IC, intracranial; oHSV, oncolytic herpes simplex virus; PFU, plaque forming unit; MOI, multiplicity of infection; IL, interleukin; Tx, treatment.

    Techniques Used: Generated, Infection, Enzyme-linked Immunosorbent Assay, Saline, Control, In Vivo, Two Tailed Test, Virus

    Related Articles

    In Vivo:

    Article Title: Oncolytic HSV-IL27 expression improves CD8 T cell function and therapeutic activity in syngeneic glioma models
    Article Snippet: Mice were injected subcutaneously with luciferin (D-luciferin sodium salt, 150 mg/kg, GoldBio). .. Antibodies used for in vivo experiments include: anti-CD8a (2.43, Leinco), anti-IL27 p28 (MM27.7B1, BioXCell), rat IgG2b isotype (LTF-2, BioXCell), mouse IgG2a isotype (N123, Leinco) and were administered by intraperitoneal injection on indicated days. ..

    Injection:

    Article Title: Oncolytic HSV-IL27 expression improves CD8 T cell function and therapeutic activity in syngeneic glioma models
    Article Snippet: Mice were injected subcutaneously with luciferin (D-luciferin sodium salt, 150 mg/kg, GoldBio). .. Antibodies used for in vivo experiments include: anti-CD8a (2.43, Leinco), anti-IL27 p28 (MM27.7B1, BioXCell), rat IgG2b isotype (LTF-2, BioXCell), mouse IgG2a isotype (N123, Leinco) and were administered by intraperitoneal injection on indicated days. ..



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    (A) Schematic illustration of C134 and C027. C134 is a second-generation oHSV with deletion of the γ134.5 genes and insertion of the human cytomegalovirus (HCMV) IRS1 gene in the UL3/UL4 intergenic region. C027 was generated from C134 by insertion of bicistronic copies of murine IL-27 (mIL27) in the deleted γ134.5 regions under the MND promoter. (B) mIL27 <t>(p28)</t> secretion from C027 or C134 infected (MOI=1) CT-2A cell supernatants at 24- and 48-hours post-infection measured by ELISA. (C) Viral replication in CT-2A cells infected with C027, C134, or WT HSV (MOI=1) demonstrating viral replication kinetics. Experimental design schematics and representative Kaplan-Meier survival curves in (D) CT-2A (n=11 per cohort), (F) KR158 (n=5- 10 per cohort), and (H) SB28 (n=10 per cohort) immunocompetent syngeneic murine glioma models (Log- Rank test of significance) after treatment with Saline or equivalent PFU (1×10 7 ) of C027 or C134 (parental control). In vivo viral recovery from murine brain tumors (E) CT-2A, (G) KR158, and (I) SB28 at two days post- treatment with C134 (n=3) or C027 (n=3). For B, C, E, G, and I, data are mean ± SEM with each shape representing one replicate or animal. Statistical analyses were performed using two-way analysis of variance with Holm-Šídák’s correction for multiple comparisons (B), unpaired two-tailed Student’s t-test (E, G, and I), or Log-Rank tests of significance (D, F, and H). IC, intracranial; oHSV, oncolytic herpes simplex virus; PFU, plaque forming unit; MOI, multiplicity of infection; IL, interleukin; Tx, treatment.
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    (A) Schematic illustration of C134 and C027. C134 is a second-generation oHSV with deletion of the γ134.5 genes and insertion of the human cytomegalovirus (HCMV) IRS1 gene in the UL3/UL4 intergenic region. C027 was generated from C134 by insertion of bicistronic copies of murine IL-27 (mIL27) in the deleted γ134.5 regions under the MND promoter. (B) mIL27 <t>(p28)</t> secretion from C027 or C134 infected (MOI=1) CT-2A cell supernatants at 24- and 48-hours post-infection measured by ELISA. (C) Viral replication in CT-2A cells infected with C027, C134, or WT HSV (MOI=1) demonstrating viral replication kinetics. Experimental design schematics and representative Kaplan-Meier survival curves in (D) CT-2A (n=11 per cohort), (F) KR158 (n=5- 10 per cohort), and (H) SB28 (n=10 per cohort) immunocompetent syngeneic murine glioma models (Log- Rank test of significance) after treatment with Saline or equivalent PFU (1×10 7 ) of C027 or C134 (parental control). In vivo viral recovery from murine brain tumors (E) CT-2A, (G) KR158, and (I) SB28 at two days post- treatment with C134 (n=3) or C027 (n=3). For B, C, E, G, and I, data are mean ± SEM with each shape representing one replicate or animal. Statistical analyses were performed using two-way analysis of variance with Holm-Šídák’s correction for multiple comparisons (B), unpaired two-tailed Student’s t-test (E, G, and I), or Log-Rank tests of significance (D, F, and H). IC, intracranial; oHSV, oncolytic herpes simplex virus; PFU, plaque forming unit; MOI, multiplicity of infection; IL, interleukin; Tx, treatment.
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    Image Search Results


    (A) Schematic illustration of C134 and C027. C134 is a second-generation oHSV with deletion of the γ134.5 genes and insertion of the human cytomegalovirus (HCMV) IRS1 gene in the UL3/UL4 intergenic region. C027 was generated from C134 by insertion of bicistronic copies of murine IL-27 (mIL27) in the deleted γ134.5 regions under the MND promoter. (B) mIL27 (p28) secretion from C027 or C134 infected (MOI=1) CT-2A cell supernatants at 24- and 48-hours post-infection measured by ELISA. (C) Viral replication in CT-2A cells infected with C027, C134, or WT HSV (MOI=1) demonstrating viral replication kinetics. Experimental design schematics and representative Kaplan-Meier survival curves in (D) CT-2A (n=11 per cohort), (F) KR158 (n=5- 10 per cohort), and (H) SB28 (n=10 per cohort) immunocompetent syngeneic murine glioma models (Log- Rank test of significance) after treatment with Saline or equivalent PFU (1×10 7 ) of C027 or C134 (parental control). In vivo viral recovery from murine brain tumors (E) CT-2A, (G) KR158, and (I) SB28 at two days post- treatment with C134 (n=3) or C027 (n=3). For B, C, E, G, and I, data are mean ± SEM with each shape representing one replicate or animal. Statistical analyses were performed using two-way analysis of variance with Holm-Šídák’s correction for multiple comparisons (B), unpaired two-tailed Student’s t-test (E, G, and I), or Log-Rank tests of significance (D, F, and H). IC, intracranial; oHSV, oncolytic herpes simplex virus; PFU, plaque forming unit; MOI, multiplicity of infection; IL, interleukin; Tx, treatment.

    Journal: bioRxiv

    Article Title: Oncolytic HSV-IL27 expression improves CD8 T cell function and therapeutic activity in syngeneic glioma models

    doi: 10.1101/2025.05.12.653429

    Figure Lengend Snippet: (A) Schematic illustration of C134 and C027. C134 is a second-generation oHSV with deletion of the γ134.5 genes and insertion of the human cytomegalovirus (HCMV) IRS1 gene in the UL3/UL4 intergenic region. C027 was generated from C134 by insertion of bicistronic copies of murine IL-27 (mIL27) in the deleted γ134.5 regions under the MND promoter. (B) mIL27 (p28) secretion from C027 or C134 infected (MOI=1) CT-2A cell supernatants at 24- and 48-hours post-infection measured by ELISA. (C) Viral replication in CT-2A cells infected with C027, C134, or WT HSV (MOI=1) demonstrating viral replication kinetics. Experimental design schematics and representative Kaplan-Meier survival curves in (D) CT-2A (n=11 per cohort), (F) KR158 (n=5- 10 per cohort), and (H) SB28 (n=10 per cohort) immunocompetent syngeneic murine glioma models (Log- Rank test of significance) after treatment with Saline or equivalent PFU (1×10 7 ) of C027 or C134 (parental control). In vivo viral recovery from murine brain tumors (E) CT-2A, (G) KR158, and (I) SB28 at two days post- treatment with C134 (n=3) or C027 (n=3). For B, C, E, G, and I, data are mean ± SEM with each shape representing one replicate or animal. Statistical analyses were performed using two-way analysis of variance with Holm-Šídák’s correction for multiple comparisons (B), unpaired two-tailed Student’s t-test (E, G, and I), or Log-Rank tests of significance (D, F, and H). IC, intracranial; oHSV, oncolytic herpes simplex virus; PFU, plaque forming unit; MOI, multiplicity of infection; IL, interleukin; Tx, treatment.

    Article Snippet: Antibodies used for in vivo experiments include: anti-CD8a (2.43, Leinco), anti-IL27 p28 (MM27.7B1, BioXCell), rat IgG2b isotype (LTF-2, BioXCell), mouse IgG2a isotype (N123, Leinco) and were administered by intraperitoneal injection on indicated days.

    Techniques: Generated, Infection, Enzyme-linked Immunosorbent Assay, Saline, Control, In Vivo, Two Tailed Test, Virus